In recent years, the beauty and health industries have seen a surge in interest surrounding innovative, natural ingredients that can deliver positive effects. One such example of this is the copper binding peptide, also known as GHK-Cu, which is a natural occurring tri-peptide present in human plasma [1]. First discovered in 1973, this powerful molecule has demonstrated capabilities in promoting health and beauty, drawing on scientific research to support its properties.
The copper binding peptide is a vital anti-ageing ingredient. It is involved in a number of crucial cellular pathways that work in different ways to protect the skin and increase cell rejuvenation. It has the ability to enhance collagen production, a protein molecule well known to strengthen the skin by increasing elasticity [2]. The copper binding peptide also increases the proliferation of fibroblasts and keratinocytes, which are cells that are released when there is injury to tissue due to their healing properties [3].
There is further evidence to show that the copper binding peptide has potent antioxidant proficiency, as it works to neutralise free radicals that contribute to premature aging and skin damage [4]. These properties show that the copper binding peptide is a key component to fight ageing by tightening skin, improving elasticity and reducing fine lines, sun damage and hyperpigmentation[4]. This allows for a healthier, youthful appearance without the use of harsh chemicals.
As well as its effective role in promoting beauty and youth, the copper binding peptide also has significant health applications. It has been shown to have strong anti-inflammatory actions by modulating inflammatory responses in the body [4]. This is an important health benefit as inflammation is considered to be a key contributor in the progression of tumour cells [5].
Furthermore, studies have shown that the copper binding peptide can stimulate regeneration in lung tissue that has been damaged in COPD (chronic obstructive lung disease) by working on gene expression [6]. With 1.2 million people in the UK alone suffering with COPD [7], this is an incredible discovery with the potential to improve the symptoms of the lung disease, allowing for a better quality of life.
Research also shows that copper binding peptides may also contribute to neuroprotection in the development of neurodegenerative disorders [8]. As the brain deteriorates with age, and the prevalence of cognitive diseases such as dementia increase in an aging population, it is crucial to keep up to date with new advances in healthcare that may help combat this.
The emergence of copper binding peptides as versatile molecules for beauty and health applications combines scientific innovation and human wellbeing. There is a growing body of research exhibiting the multi-faceted properties of copper binding peptide on a cellular level as a safe and natural ingredient. Its ability to repair DNA [4], promote cell regeneration, function as an anti-oxidant and anti-inflammatory agent show that it is essential in maintaining good health.
Author: Dr Sharif (MBBS)
Bibliography
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences [Internet]. 2018 Jul 7;19(7). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/
- Holwerda AM, van Loon LJC. The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling: a narrative review. Nutrition Reviews. 2021 Oct 4;80(6).
- Shaw TJ, Martin P. Wound repair at a glance. Journal of Cell Science. 2009 Sep 2;122(18):3209–13.
- Pickart L. The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science Polymer Edition [Internet]. 2008;19(8):969–88. Available from: https://pubmed.ncbi.nlm.nih.gov/18644225/
- Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec;420(6917):860–7.
- Pickart L, Margolina A. Skin Regenerative and Anti-Cancer Actions of Copper Peptides. Cosmetics. 2018 Apr 21;5(2):29.
- NHS. Digital service to manage high-risk chronic obstructive pulmonary disease (COPD) patients [Internet]. NHS Transformation Directorate. Available from: https://transform.england.nhs.uk/key-tools-and-info/digital-playbooks/respiratory-digital-playbook/digital-service-to-manage-high-risk-chronic-obstructive-pulmonary-disease-copd-patients/#:~:text=In%20the%20UK%2C%201.2%20million
- Pickart L, Vasquez-Soltero JM, Margolina A. The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health. Oxidative Medicine and Cellular Longevity. 2012;2012:1–8.
